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Monday, October 31, 2016

Quality of Life Labs, Kinoko Gold AHCC, Immune Support

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What is AHCC?



The world's most researched specialty immune supplement supported by 20 human clinical studies, by over 30 papers published in PubMed-indexed journals and by more than 100 pre-clinical and in vitro studies.


Japan's leading alternative cancer therapy used in hundreds of cancer clinics throughout Asia.


Highly effective immuno-modulator used in over 700 clinics as a standard preventative regiment for all incoming patient to reduce the risk of hospital infections.


The daily immune supplement of tens of thousands of healthy people in Japan and worldwide, seeking to help their bodies to fight the formation of abnormal cells, whose growth can lead to cancer, chronic disease and infections (such as the influenza / flu virus).



How does AHCC work?


AHCC has been used successfully to treat a wide range of health conditions, from minor ailments such as colds and flu, to serious diseases such as cancer, hepatitis, diabetes, and cardiovascular disease.
How can one dietary ingredient be effective against so many types of health problems?

The answer is that many acute and chronic conditions share a hidden cause: compromised immunity. And as a biological response modifier, AHCC turns the dial up on your natural immune response, helping you fight all kinds of threats to your health.

An Immune System Primer
The immune system's job is to protect you from harm. It is always scanning your body to determine if bacteria, viruses, toxins, parasites and other pathogens have entered your system or if any of your cells have mutated and become abnormal.

You have two basic types of immunity: innate and adaptive. Your innate immunity launches an immediate, non-specific attack against a threat. Your adaptive immunity takes longer to kick in, but produces a specific response to a particular microbe.

Key Players of Innate Immunity: Your First Line of Defense

  • Cytokines: Chemical messengers that help immune cells communicate and coordinate an immune response
  • Natural killer (NK) cells: White blood cells (WBC) that recognize and destroy infected or abnormal cells by injecting granules into them, causing them to explode
  • Macrophages: WBC that engulf and ingest bacteria and cellular debris
  • Dendritic cells: WBC that present foreign substances to B and T cells, initiating an adaptive response

Key Players of Adaptive Immunity: Your Second Line of Defense

  • B and T cells: Both B cells (which mature in bone marrow) and T cells (which mature in the thymus) are lymphocytes, WBC that are able to recognize previous invaders and destroy them with a specific response
.

Proven Benefits of AHCC
In vivo and human clinical trials have shown that AHCC modifies both the innate and adaptive immune response, by:

  • Increasing the production of cytokines
  • Increasing the activity of NK cells by as much as 300-800%
  • Increasing populations of macrophages, in some cases doubling them
  • Increasing the number of dendritic cells
  • Increasing the number of T cells by as much as 200%

AHCC, Kinoko Gold, cancer, iherb coupon



A cultured extract of medicinal mushroom mycelia (roots), AHCC is one of the world's most researched specialty immune supplements, supported by over 20 human clinical studies.
Studies on AHCC have been conducted at some of the finest research institutions worldwide, including highly regarded Ivy League universities.







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AHCC has been shown to:
  • Maintain optimal NK cell activity
  • Enhance cytokine production
  • Promote optimal T-cell activity
  • Promote optimal macrophage activity
  • Increase the activity and number of dendritic cells
Unlike most other medicinal mushroom extracts, AHCC has a very low molecular weight of just 5,000 daltons and is rich in alpha-glucans increasing absorption and efficacy. Because of its superior supporting research, AHCC is used by an estimated 1000 clinics worldwide.








Herbs Etc., ChlorOxygen, Chlorophyll Concentrate, Alcohol Free, 1 fl oz (29.6 ml)

ChlorOxygen, Chlorophyll, iherb coupon

Description
  • Highly Concentrated
  • Solutions You Trust Since 1969
  • Gluten Free
  • Preservative and Alcohol Free
  • No Refrigeration Required
  • 36 Drops= 100 mg Chlorophyll
  • Great Sweet Grass Taste
  • #1 Seller SPINS Data
  • Herbal Supplement


Increased oxygenation is the body's key to producing more energy. ChlorOxygen chlorophyll concentrate satisfies your body's hunger for oxygen in two ways.

First, as red blood cells travel through your lungs, ChlorOxygen activates these cells and turns them into irresistible magnets for oxygen.
Delivered to your tissues, this abundant oxygen satisfies your hungry cells and your energy surges.
Then, ChlorOxygen builds better blood by providing your body with the building blocks necessary to produce and maintain healthy levels of red blood cells.

Boost your energy levels naturally with ChlorOxygen. It energizes without sugar, caffeine, or other stimulants.


Herbs, Etc., Makers of Exceptional Herbal Medicines
For over 45 years, Herbs, Etc. has been harnessing the healing properties of herbs. We create and deliver professional strength formula-based natural medicines that are unique, safe, and effective.

  1. Builds Better Blood
  2. Satisfies your body's hunger for oxygen
  3. Boosts energy levels
  4. Increases hematocrit levels during pregnancy
  5. Maximizes lung function
  6. Helps altitude acclimation
  7. Equals up to two 16 oz. of the competition's chlorophyll

You can find ChlorOxygen at Iherb.com


Culturelle, Kids Packets, Probiotic, 30 Single Serve Packets

Culturelle, Kids Packets, Probiotic, iherb coupon
Description
With 5 Billion Active Cultures!
#1 Pediatrician Recommended Brand††
Helps Supports Kids' Natural Defense Systems
Helps Reduce Occasional Digestive Upset
Easy to Take & Flavorless
Dairy & Gluten Free
Probiotic Supplement with Naturally Sourced Lactobacillus GG
Good Housekeeping Since 1909
#1 World's Most Researched Probiotic
Supporting kids' natural defense systems is important to promoting their overall health as well as helping to alleviate occasional digestive distress. 
Culturelle Kids Packets support a child's health by fostering the proper balance between good bacteria and the non-beneficial bacteria that resides in the gastrointestinal tract.
Culturelle Kids Packets contains Lactobacillus GG, the most clinically studied probiotic strain.††† 
It is demonstrated to survive harsh stomach acids to get where it's needed most in the intestines and is recognized as safe for regular use. 
Research has shown that Lactobacillus GG alleviates occasional digestive distress while supporting a child's natural defenses.

Certificate of Purity & Potency
The Lactobacillus GG strain (Lactobacillus rhamnosus GG-ATCC 53103) was discovered in 1985 at Tufts University in Boston, MA. Considered the premier probiotic in the world, Lactobacillus GG has been the subject of over 800 scientific studies.
Culturelle is the only dietary supplement brand with 100% Lactobacillus GG. We certify that our products meet the highest standards of purity and potency. 
Unlike some products which measure the number of probiotic cultures at time of manufacture, Culturelle guarantees the 
stated number of live naturally sourced Lactobacillus GG Cultures through the expiration date on the package.
Trust your gut to Culturelle.

Benefits of Culturelle Kids Packets Daily Probiotic Formula withLactobacillus GG


  • Contains 100% naturally sourced Lactobacillus GG – the #1 most clinically studied probiotic††
  • Supports a child’s health by fostering the proper balance of good bacteria in the gastrointestinal tract*
  • Helps support kids’ natural immune systems*
  • Helps reduce occasional digestive upset in kids – including diarrhea or general discomfort*
  • Culturelle Kids Packets Daily Probiotic Formula are easy to take (especially for little ones)
  • Flavorless, so you can add your child’s probiotics to any cool liquid or food
  • Contains none of the following: gluten, dairy,≠≠ lactose, milk, added colors, preservatives, yeast or soy

††Based on a 2012 survey among pediatrician recommending a probiotic brand
†††Based on the number of Lactobacillus GG clinical studies, as of August 2014



Sunday, October 30, 2016

Milk Thistle Benefits: Detox the Liver & Boost Glutathione


Milk thistle, a natural herb that has antioxidant and anti-inflammatory properties, is commonly used to detoxify the body, especially the liver. Milk thistle (which has the scientific name Silybum marianum) is a weed that grows mostly in California (although it can be grown in many parts of the world with a warm climate) that’s commonly turned into extract or supplement form in order to reap its cell regenerating milk thistle benefits.

As an herb that’s considered a “hepatic, galactogogue, demulcent and cholagogue,” milk thistle is able to promote healthy digestive function by helping with enzyme formation, increasing bile production, decreasing inflammation and soothing the mucous membranes throughout the body.

How Milk Thistle  Work

Milk thistle has actually been used for over 2,000 years. The plant is native to the Mediterranean region and a member of the Asteraceae plant family, which also includes other plants like sunflowers and daisies. The Greek physician and botanist Dioscorides was the first to describe milk thistle’s healing properties back in the year 40 A.D.

Milk thistle benefits work by drawing toxins out of the body that can cause a range of symptoms and diseases — including cancer development, high cholesterol, diabetes, kidney stones, gall bladder disorders, negative effects of chemotherapy, alcohol use, skin damage and much more. 

As an antioxidant, milk thistle is equally powerful to other important nutrients like vitamin E or vitamin C, which help fight free radical damage and slow the aging process that can lead to disease development. It specifically contains high levels of lipophilic extracts from the seeds of the plant, which act as bioflavanoid antioxidants that increase immunity and slow down oxidative stress. 

While it has many different benefits, milk thistle is most well-known for being a natural liver supporter and detoxifier. The liver constantly works hard to help defend us from toxins that are common in our everyday life, acting like a filter and removing harmful substances from the body.

Milk thistle is shown to decrease, or even reverse, damage to the liver that’s been caused by prescription medications, antibiotics, pollution, heavy metals and so on.

The seeds and leaves of the milk thistle plant can be consumed either in pill, powder, tincture, extract or tea form. The seeds can actually be eaten completely raw too, but usually people prefer to take a milk thistle extract or supplement in order to consume a higher dose and see bigger results.

Milk thistle gets its name from the milky-white liquid that runs off of the plant’s leaves when they’re crushed. The actual leaves of the plant also have a spotted white pattern that makes them look as if they’ve been dunked in milk.

Milk Thistle Benefits



1. Liver Detoxification & Health

As a liver support and liver aid, milk thistle is a powerful detoxifier. It helps rebuild liver cells while removing toxins from the body that are processed through the liver. Milk thistle is effective at naturally reversing the harmful effects of alcohol consumption, pesticides in our food supply, heavy metals in our water supply, pollution in the air that we breathe in and even poisons!

The liver is actually our largest internal organ and is responsible for performing a number of essential detoxifying functions. The condition of our blood throughout our whole body is mostly reliant on the health of our liver. As a “blood purifier,” the liver needs to actively clean the blood each and every day in order to support nearly every system within our body.

The liver helps remove harmful substances from our blood, aids in hormone production, detoxifies the body, releases glucose into the bloodstream in order to give our body steady energy and releases bile into our small intestine so fat can be absorbed from foods. You can see why poor liver function can create so many problems!

Milk thistle has been approved as a therapeutic treatment for various liver diseases, including fatty liver syndrome, damage from alcoholism, jaundice, psoriasis, hepatitis and others. 

2. Helps Protect Against Cancer


Milk thistle seeds are a high source of the antioxidant flavonoid called silymarin. Silymarin is associated with decreasing the risk for cancer development by boosting the immune system, fighting DNA damage and reversing cancerous tumor growth.

In 2007, after reviewing numerous studies involving milk thistle therapeutic treatments, researchers at the University of Minnesota found that:

“There is strong preclinical evidence for silymarin’s hepatoprotective and anticarcinogenic effects, including inhibition of cancer cell growth in human prostate, skin, breast, and cervical cells.” 

About 50 percent to 70 percent of the silymarin molecules present within milk thistle are the type called silybin. This antioxidant stimulates protein synthesis and changes the outside layer of healthy cells, keeping them protected from damage and mutation. It inhibits toxins from dwelling in the body; helps with cell renewal; and counteracts the harmful effects of pollutants, chemicals and heavy metals that can cause “free radical damage.”

Silymarin acts as a cancer protector because it’s “a toxin blockade agent” and inhibits binding of toxins to the cell membrane receptors, according to researchers at the University Magna Graecia Department of Experimental and Clinical Medicine. 

3. Can Help Lower High Cholesterol


The U.S. National Library of Medicine considers milk thistle to be a powerful anti-inflammatory, stopping inflammation, which is one of the main causes of heart disease. Milk thistle benefits heart health and helps lower high cholesterol levels by lowering inflammation, cleaning the blood and preventing oxidative stress damage within the arteries.

Although more formal research is still needed, preliminary studies show that when syilymarin milk thistle extract is used in combination with other traditional treatment methods, total cholesterol, low-density lipoprotein (LDL or “bad”) cholesterol and triglycerides levels all improve compared to levels before taking milk thistle. 

Something important to keep in mind, however, is that existing studies on possible heart benefits of milk thistle have only been done involving people with diabetes, who tend to have high cholesterol levels. So at this time it’s unclear if milk thistle has the same effects in other people and if it will be used to naturally lower cholesterol levels in the future.

4. May Help Control or Prevent Diabetes


According to National Institute of Health, there’s some compelling research showing that taking silymarin, the main chemical found in milk thistle, along with conventional treatments can help control symptoms of diabetes by helping with glycemic control. The valuable effect of antioxidants found in milk thistle has been reported in experimental and clinical studies to help decrease blood sugar levels in insulin-resistant patients.

One 2006 study conducted by the Department of Pharmacology at the Institute of Medicinal Plants found that when diabetic patients were given silymarin extract over four weeks, their fasting blood glucose and insulin levels improved significantly compared to patients receiving a placebo. 

This is likely true because the liver is partly responsible for regulating hormones, including the release of insulin into the bloodstream. Insulin is responsible for managing blood glucose (sugar) levels in the blood, which is especially important for those with diabetes.

5. Helps Prevent Gallstones

The liver is a major digestive organ, helping process nutrients and toxins that enter our body through foods, water and air. Because the liver and other digestive organs — like the gallbladder, pancreas, intestines and kidneys — work closely together to improve liver health so much, milk thistle is also able to help prevent gallstones and kidney stones.

Milk thistle benefits help support the endocrine and gastrointestinal systems by aiding in the production of bile and enzymes, on top of helping clean the blood. Milk thistle can help purify the body of metabolic waste, thereby regulating the function of the gallbladder, in addition to the kidneys and spleen.

6. Boosts Skin Health 


Studies show that phytochemicals, like those found in silymarin of milk thistle, are effective at inhibiting UV light-induced oxidative stress on the skin. Milk thistle is considered to be a potent inhibitor of UV-induced oxidative stress that can cause skin diseases like skin cancer. Research also suggests that applying silymarin found in milk thistle to the skin reduces skin damage caused by radiation treatment in patients who have had treatments for cancer. 

In 2008, when researchers from the Department of Dermatology at the University of Alabama Birmingham compared the effects of strong UV light exposure on the skin of mice, mice who received milk thistle extract showed much less damage on the skin than the mice who did not receive milk thistle.

7. Has Anti-Aging Effects


Because milk thistle’s antioxidants help prevent free radical damage throughout the body and remove pollutants and waste from the blood and digestive tract, it can actually slow the aging process. This is true on both the surface of your skin and also within your organs.

Milk thistle benefits can also reduce your risk for some of the most common and serious disorders that develop in adults as they age, including heart disease, cancer, diabetes, kidney and liver damage, aged skin, and vision-related problems.

Milk thistle’s protective qualities of the skin make it great for reducing visible signs of aging, so consuming milk thistle can be an easy way to prevent skin cancer and skin damage, such as dark spots, wrinkles, lines and discoloration.  The same antioxidant properties make it useful for maintaining the health of your eyes, joints and muscles.


Milk Thistle and Glutathione


Silymarin, the active ingredient in milk thistle, is an antioxidant that can protect against depletion of glutathione, which is a “master antioxidant” that’s extremely useful at helping prevent disease formation. Glutathione is found naturally in the human body, as well as in some plants, mushrooms, fungus and algae.

Its biggest role is to help fight oxidative stress that leads to such diseases as cancer, diabetes, heart disease and neurodegenerative diseases. It can help prevent damage to important cellular components caused by reactive oxygen species, such as free radicals.

One of the biggest milk thistle benefits is that it preserves glutathione. The modern American diet, pollution, toxins, medications, stress, trauma, aging, infections and radiation all work to deplete liver capabilities and also glutathione in the body. Milk thistle helps increase glutathione levels by improving liver detox functions. Milk thistle strengthens the liver cell walls, buffering them from invading toxins, and supports liver regeneration and glutathione formation.

Recommended Dosage of Milk Thistle

Because milk thistle is categorized as a supplement, rather than a drug, it’s not subject to the same oversight and quality control from the FDA that standard drugs are. The amount of active ingredients can vary widely depending on the different preparation methods used and the brand. Currently, there are several different compounds available on the market, all recommending different doses.

Dosing hasn’t been nationally standardized yet at this time, but most people do best consuming between 20-300 milligrams daily.

Supplement form:

As a way to detoxify the body temporarily, the recommended daily intake of milk thistle is 150 milligrams, taken one to three times daily. This is a somewhat high dose that can act as a natural liver “detox.”

For ongoing use and liver support, take 50 to 150 milligrams daily.

Look for a high-quality product that’s between 50–150 milligrams of pure milk thistle extract per capsule so you can adjust the amount you are taking depending on your needs. And make sure to look for a company that sells highly potent extract labeled at least 80 percent pure milk thistle extract.

Milk Thistle Side Effects

Milk thistle is considered safe and well-tolerated, with very few cases of side effects ever reported. The most common side effects aren’t serious and include gastrointestinal upset, such as a mild laxative effect. When taken within the recommended dose range, milk thistle is thought to be effective and mostly free of allergic reactions and interactions. 


Milk thistle CAN BE FOUND AT IHERB.COM 



Saturday, October 29, 2016

How PQQ Protects the Brain

Anti-aging supplements, antioxidants, cardiovascular health, CoQ10, health, healthy living, PQQ, Supplements.

PQQ is the acronym for pyrroloquinoline quinone.
PQQ remains a little-known essential component of all living things.
It has not become a popular supplement because there currently is a limitation on the amount of PQQ that can be produced. Only a tiny fraction of the American population is able to access it now. That has not stopped scientific exploration into its biological effects.
Researchers are uncovering how PQQ functions as a neuroprotective agent that can help protect memory and cognition.
While only discovered about 50 years ago, scientists have been actively exploring the benefits of PQQ in healing the brain.
In an exciting new discovery, PQQ has been found to increase the formation of new nerve cells.
In addition, researchers have found that PQQ can promote growth of new mitochondria! This is an important longevity strategy that can help prevent the diseases of aging.
During the life span, the brain suffers from multiple sources of damage. As these effects accumulate, the result is often the development of neurodegenerative disorders, as well as the risk of stroke from progressive injury to brain blood vessels. Brain trauma is yet another way that the delicate microstructure of brain cells is disrupted, leading to loss of cognition and function.
PQQ has been found to help guard the brain against these major brain-threatening processes by a variety of mechanisms related to improving brain energy metabolism.

Threats to the Brain

While dementiastroke, and brain injury may appear to be unrelated events, they all share fundamental processes that contribute to the eventual loss of brain cells and the decline in cognitive abilities.
Mainstream medicine tends to focus on managing each condition after it has emerged. By that time, much of the damage has already occurred. A more effective approach is to attack the underlying degenerative processes all at once, before irreversible damage is done.
That’s what PQQ does.
Let’s examine the most common factors that contribute to aging brains and the impact that PQQ supplementation has against each of those factors. This provides an understanding as to how this molecule functions.

PQQ Promotes New Mitochondrial Formation

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Recent studies corroborate the unique ability of PQQ to stimulate the formation of new mitochondria and improve the function of existing mitochondria.
It would be difficult to overstate the dramatic impact this has on the entire body, especially the brain. Mitochondria are responsible for converting the food we eat into the energy that powers cells to perform at peak function. Unfortunately, mitochondrial function declines with age. This decline has been linked to virtually all killer diseases of aging, including Parkinson’s and Alzheimer’s.
Creating new mitochondria is an important longevity strategy that can help ward off the diseases of aging.
Numerous preclinical studies show that PQQ rejuvenates mitochondrial function and restores mitochondria numbers. Importantly, this has led to the prevention of cognitive impairments, and was also shown to improve the gait disturbances seen in Parkinson’s disease.
An exciting human study has further demonstrated that PQQ supplementation improves mitochondrial function. A single dose of PQQ (equaling 13 mg for an average-sized adult) led to improved measurements of urinary oxidant levels (indicators of mitochondrial efficiency).
This team of scientists also evaluated the impact of a higher daily dose of PQQ supplementation after three days (equaling about 20 mg per day for an average-sized adult) and found that measurements of inflammation (such as C-reactive protein and interleukin-6) were decreased.

PQQ Promotes Nerve Cell Growth

In a stunning development, PQQ was found to stimulate previously unknown healing processes in the brain, leading to the formation of brand-new nerve cells. Nerve cells transmit messages throughout the body in order to regulate everything from the nervous system to organ function.
Laboratory experiments have determined that one of the ways PQQ promotes the development of new nerve cells is through stimulation of nerve growth factor (NGF) in brain cells. In fact, PQQ proved to be far superior to other molecules aimed at stimulating nerve growth factor in cultures of brain cells.
Nerve growth factor is a small protein molecule that is required for the development and maintenance of nerve cells, including many of the cells that are critical for memorycognition, and learning.
Nerve growth factor is particularly important for maintaining nerve plasticity, the process by which nerve cells form connections in order to communicate with each other. Essentially, this is what allows us to engage in the process of learning and memory.
By stimulating the production and release of nerve growth factor in cells that support neurons, PQQ has been found to protect memory and cognition in aging animals and humans.
Lab experiments have shown PQQ’s ability to promote the healing of injured nerves.In one study, scientists inserted tubes containing PQQ into areas where nerves had been severed. New nerve tissue eagerly filled the gaps, increasing the number and diameter of individual fibers, effects not seen in control animals.
Another means by which PQQ impacts new nerve cell development is by protecting nerve stem and progenitor cells from oxidative damage. This allowed these cells to survive and potentially form new brain cells.
WHAT YOU NEED TO KNOW
PQQ Provides Potent Neuroprotection

PQQ Provides Potent Neuroprotection

  • The current global epidemic of cognitive decline and dementia threatens everyone’s hopes for healthy aging. There is also an increase in strokes and traumatic brain injury.
  • The unique chemical compound called PQQ shows the ability to slow or reverse cognitive decline and dementia by targeting a variety of mechanisms.
  • Lab studies and animal experiments demonstrate that PQQ promotes brain cell survival and improves cognitive function by protecting cellular metabolic processes and enhancing nature’s own healing and protective mechanisms.
  • PQQ should form an important part of a supplementation regimen for those concerned about supporting and preserving brain health.


PQQ Protects against Oxidative Damage

Numerous studies demonstrate that PQQ improves brain function.
Improvements in learning ability and memory were seen in rats supplemented with PQQ. Researchers attribute this to PQQ’s ability to reduce oxidative damage.
These results were confirmed in a later study of healthy older rats. In this study, PQQ was found to boost the ability of older rats to learn new information and help the animals use that memory after a prolonged period. The researchers attributed this increase both to relief of oxidative damage and also to enhanced production of nerve growth factor.
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Neurodegenerative Diseases

Oxidative damage is one of the key factors leading to neurodegenerative diseases. Studies have demonstrated that PQQ’s ability to fight oxidative damage makes it of special interest in treating Parkinson’s disease.
Lab studies show that in the presence of PQQ, cells exposed to a toxin that induces oxidative damage are protected against death and fragmentation of their DNA. This demonstrates its potential use against Parkinson’s.

Ischemic Stroke

PQQ could also play an important role in protecting the brain from the devastation of a stroke.
An ischemic stroke occurs when the loss of blood supply to a specific area of the brain deprives the brain of the essential nutrients/oxygen it needs. The result is brain cell death and loss of function reflected in the region of the brain where the damage occurred. Depending on the area affected, this can result in paralysis, memory impairment, and even death.
In lab studies, PQQ reduced ischemic damage, potentially improving the quality of life following a stroke.
This was clearly demonstrated in an animal model of ischemic stroke. When PQQ supplementation was given beforeischemia was induced, it significantly reduced the size of the damaged brain tissue region. Surprisingly, PQQ had a similar protective effect even when it was administered after the ischemia was induced.
Another study showed similar neuroprotective effects. It also showed that PQQ led to significantly improved neurobehavioral scores after the stroke.These findings are tremendously exciting for those working in the area of human stroke prevention and treatment. The implication is that stroke patients could be given PQQ in the emergency room and reduce paralyzing brain damage.

PQQ Reduces Harmful Neuroinflammation

PQQ Reduces Harmful Neuroinflammation  
Neuroinflammation directly damages brain cells and accelerates the aging process.
Chronic, low-grade inflammation of the brain is common to many neurodegenerative diseases. It also occurs following a stroke and traumatic brain injury. Other causes of neuroinflammation include infection, oxidative damage, and the effects of high glucose levels.
Studies show that PQQ supplementation markedly reduces harmful neuroinflammation. One of the ways it does this is by inhibiting the production of two pro-inflammatory signaling molecules.
Neuroinflammation is especially damaging following a traumatic brain injury. In a recent study conducted at the University of Maryland School of Medicine, the researchers argued that inflammation is to blame for many of the symptoms of traumatic brain injury, including brain atrophy and cognitive decline.
Fortunately, an animal study published in the Journal of Neurotrauma shows that by protecting against neuroinflammation, PQQ can help to protect against some of the effects of traumatic brain injury.

PQQ Protects against Excitotoxicity

Excessive glutamate stimulation of brain cells, or excitotoxicity, is a major factor in the development of long-term neurodegenerative disorders, stroke, and schizophrenia.
Glutamate-induced excitotoxicity triggers undesired programmed cell death (apoptosis).
Fortunately, not only can PQQ help protect against the damaging effects of excitotoxicity, it can also help prevent it from occurring to begin with.
Studies of cultured cells from the hippocampus (the brain’s major memory-processing center) reveal that PQQ reversesoxidative damage caused by excitotoxicity. PQQ accomplishes this by turning on protective genes and signaling molecules that protect brain cells. PQQ also modulates the cellular receptor that triggers an excitatory response. This helps to prevent these dangerous responses from occurring in the first place.
In a powerful study demonstrating PQQ’s protective effects against excitotoxicity, researchers directly injected rat brains with glutamate. As expected, oxidative damage rose abruptly and brain cells began to die off because of the glutamate surge.
However, when rats were given glutamate and PQQ at the same time, it produced an entirely different picture. The presence of PQQ significantly reduced cell death and decreased oxidative damage. As an added benefit, PQQ increased the expression of a host of intracellular protective systems and growth factor regulators, resulting in both protection from damage and a head start on recovery.

PQQ Prevents Glucose-Induced Brain Damage

One of the least-known consequences of the diabetes epidemic is damage to brain cells from chronic exposure to elevated blood sugar levels. It is alarming that people with diabetes are 60% more likely to develop dementia. In addition, the elevated insulin levels associated with diabetes may also contribute to neurological damage. This has led many scientists to refer to Alzheimer’s disease as “type III diabetes.”
PQQ can help protect the brain against the damage caused by high blood sugar. When researchers exposed cells from brain blood vessels in the lab to high blood sugar concentrations, it resulted in high rates of cell death.However, when PQQ was added to the cells’ growth medium, it reversed the high-glucose damage, suppressed cell death, andreduced the production of dangerous reactive oxygen species.
These protective effects were also seen in animal studies. In fact, PQQ, at a dose equivalent to about 100 mg in a human, significantly reversed brain cell damage in diabetic mice.44 The recommended dose of PQQ supplementation for aging humans is 20 mg each day.

PQQ Inhibits Malformed Brain Proteins

Anti-aging supplements, antioxidants, cardiovascular health, CoQ10, health, healthy living, PQQ, Supplements, IHERB COUPON  
One of the main contributing factors in the development of Alzheimer’s and Parkinson’s diseases is the accumulation of malformed proteins. In Alzheimer’s, these are collectively referred to as beta amyloid. Beta amyloid proteins cause a tremendous amount of damage and ultimately kill brain cells.
When PQQ was applied to brain cells in culture, it showed impressive abilities to save and revive dying cells. PQQ reversed the toxicity of beta amyloid proteins, prevented the death of brain cells, reduced oxidative damage caused by this malformed protein, and revived those cells that had begun to die.45
In Parkinson’s disease, the abnormal protein deposits in the brain contain tangled fibrils of a protein called alpha-synuclein that is toxic to brain tissue. PQQ prevents the formation of these cell-killing fibrils, which helps protect cells against oxidative damage.
Excitement is growing in the scientific community about PQQ’s ability to inhibit the formation of toxic protein fibrils in both Alzheimer’s and Parkinson’s diseases.

Summary

Loss of brain function leads to cognitive decline, memory loss, and a gradual diminution of the self.
While neurodegenerative diseases, strokes, and brain injury appear to be different processes, a look at the cellular events involved show remarkable similarities.
Mainstream medical practice believes these degenerative processes are inevitable. The result is most physicians focus only on clinical endpoints, which is rarely successful in restoring lost cognitive function.
A more rational approach is to address the fundamental problems of neurodegeneration together, with the aim of preventing further damage and restoring what can still be repaired.
PQQ has demonstrated robust effects against major brain-aging pathological processes.

You can find natural BioPQQ™ form at iherb.com