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Monday, November 21, 2016

Vitamin B12 deficiency

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I used to think that taking a Centrum multivitamin would take care of all my body’s nutritional needs. Now I know better. 
Most over the counter supplements are not monitored for quality or content by an independent lab and frequently do not contain the ingredients advertised. At any rate, I would much rather get my vitamins from my produce section and farmer’s market than from a bottle, but , sometimes food sources just are not enough. 
There are certain vitamins that are commonly lacking from our diets and require supplements. 
Vitamin D, for example, get a lot of press. You may not know about another common deficiency- a critical “B” vitamin – B12. 
Women with PCOS become depleted of B12 for many reasons with serious consequences such as fatigue, lethargy, weakness, memory loss, neurological and psychiatric problems and anemia. 
Frighteningly, many common diseases (such as Alzheimer’s Disease, cardiovascular disease, mental illness, autoimmune disease and more) have symptoms that mimic those of B12 depletion and are easily misdiagnosed. 
What is B12? 
According to Wikipedia, “B12 is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood. It is one of the eight B vitamins. It is normally involved in the metabolism of every cell of the human body, especially affecting DNA synthesis and regulation, but also fatty acid synthesis and energy production. 
It is the largest and most structurally complicated vitamin.” 
Who is low in B12? 
Data from the Tufts University Framingham Offspring Study suggests that 40 percent of people between the ages of 26 and 83 have plasma B12 levels in the low normal range – a range at which many experience neurological symptoms. 9 percent had deficiency, and 16 percent exhibited “near deficiency.” Most surprising to the researchers was that low B12 levels were common in younger people. 
Where do you get B12?Vegetarians and vegans take note! 
B12 is only found in animal based food. Here are some of the top B12 containing foods. Mollusks (clams, oysters, mussels0 Beef liver Salmon Wild trout Sirloin Beef Yogurt Milk Pork Eggs Chicken.
Vegetarians and vegans should understand that there are no plant sources of B12, and studies consistently show that up to 50% of long-term vegetarians and 80% of vegans are deficient in B12. 
The symptoms of B12 deficiency: 
  • Premature grey hair 
  • Disturbed carbohydrate metabolism 
  • Fatigue 
  • Weakness 
  • Dizziness 
  • Weight loss 
  • Constipation 
  • Infertility 
  • Vision problems 
  • Loss of hearing and tinnitus 
  • Numbness and tingling in the hands and feet 
  • Alcoholism Incontinence 
  • Hyperpigmentation and hypopigmentation (dark and light patches in the skin) 
  • Psoriasis and other skin problems 
  • Insomnia 
  • Irrational or chronic anger 
  • Violent behavior 
  • Lack of balance/abnormal gait 
  • Any emotional disorder 

A Note about B12 and infertility 
“Vitamin B12 deficiency is associated with infertility,” says hematologist Michael Bennett, M.D. in Could it be B12? “Pregnancy may occur in the presence of B12 deficiencybut may be associated with recurrent early fetal loss.” Luckily, supplementation can help. Doctors have reported successful pregnancies in once-infertile women following therapy for B12 deficiency. If you are going through fertility treatments, insist on a B12 test. 
What causes B12 deficiency? 
There are many causes of B12 deficiency ranging from poor diet, to medication side effects to other medical conditions (such as leaky gut and/or gut inflammation, low stomach acid, pernicious anemia, alcohol use, and exposure to nitrous oxide). 
Metformin causes B12 deficiency 
I know when I was taking metformin, my doctor never told me that I could become B12 deficient and was never told to supplement. If you have PCOS and are taking metformin, talk to your doctor about supplementing with B12 and have your levels checked regularly. Bring your doctor the summaries of the studies associated below. 
Oral contraceptives may cause B12 deficiency 
The data regarding the effects of oral contraceptives on vitamin B12 serum levels are conflicting. Some studies have found reduced levels in oral contraceptive users, but others have found no effect despite use of oral contraceptives for up to 6 months. When oral contraceptive use is stopped, normalization of vitamin B12 levels usually occurs. Again you can bring the study summaries to your doctor. Most women are taking metformin and OC’s – a double whammy! 
What tests can I take to know if I am low in B12? 
B12: Normal values are 200 – 900 pg/mL (picograms per milliliter). 
CBC (Complete Blood Count). This is actually a group of tests ordered routinely to screen for blood cell abnormalities. It measures cell types, quantities, and characteristics. With both B12 and folate deficiencies, the amount of hemoglobin and RBC count may be low, and the RBCs are abnormally large (macrocytic or megaloblastic), resulting in an anemia. White blood cells and platelets also may be decreased. 
Methylmalonic Acid (MMA). This is sometimes ordered to help detect mild or early B12 deficiency. A normal serum sMMA level is .07 to .27 µmol/l. A normal urine uMMA level is .58 – 3.56 µmol/mmol 
Homocysteine(HCY). This one is only occasionally ordered. Levels may be elevated in both B12 and folate deficiency. A normal serum HCY is 2.2 – 13.2 µmol/l 
If MMA and homocysteine levels are increased and the vitamin B12 level is mildly decreased, then an early or mild B12 deficiency may be present. This may indicate a decrease in available B12 at the tissue level. If only the homocysteine level is elevated, then the person may have a folate deficiency. If both MMA and homocysteine levels are normal, then it is unlikely that there is a B12 deficiency. 
Supplementing B12 
The most commonly used form of supplemental B12 in the US is cyanocobalamin – that is what you will find in your Centrum vitamins. However, only two forms of B12 are active in the body – methylcobalamin and adenosylcobalamin. Cyanocobalamin must be converted in the body to either methyl or adenosyl cobalamin. But if you supplement with methylcobalamin, your body can immediately use this active form of vitamin B12 which is available at most health food stores in the US. It can be supplemented in pill form, sublingual tablet, liquid, transdermal patch, nasal spray, and even lollipop. 
 I personally sourced it from the most reputable nutraceutical company I could find to ensure quality and consistent effectiveness. It is specifically designed for women with PCOS and contains the critical B12 as methylcobalamin
If your B12 is really low your doctor may prescribe injections. The standard protocol is 1000 micrograms daily for three days, then weekly for a month, then one injection per month indefinitely. 
Be sure that you chose a B12 supplement that is verified by a third party, independent lab or you cannot be certain that the quality or quantity you are consuming is accurate. In some cases, uninspected supplements contain none of the nutrient advertised! 













Sunday, November 20, 2016

Heal Leaky Gut and Autoimmune Disease

Leaky gut syndrome is a rapidly growing condition that millions of people are struggling with and don’t even know it. From the sound of it, you might think leaky gut syndrome only affects the digestive system, but in reality it can lead to many other health conditions.
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According to research, the cause of your food allergies, low energy, joint pain, thyroid disease, autoimmune conditions and slow metabolism could be leaky gut symptoms progression.
In this article, I will outline specifically how you can heal leaky gut syndrome and break through the health problems you’ve been struggling with.

What Is Leaky Gut Syndrome?

Think of the lining of your digestive tract like a net with extremely small holes in it that only allow specific substances to pass through. Your gut lining works as a barrier keeping out bigger particles that can damage your system.
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When someone has leaky gut (often referred to as increased intestinal permeability), the “net” in your digestive tract gets damaged, which causes even bigger holes to develop in your net, so things that normally can’t pass through, are now be able to.
Some of the things that can now pass through include proteins like gluten, bad bacteria and undigested foods particles. Toxic waste can also leak from the inside of your intestinal wall into your bloodstream causing an immune reaction.
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Leaky Gut Symptoms and Progression

This leads to inflammation throughout your system and can cause symptoms, such as:
  • Bloating
  • Food sensitivities
  • Thyroid conditions
  • Fatigue
  • Joint pain
  • Headaches
  • Skin issues like rosacea and acne
  • Digestive problems
  • Weight gain
  • Syndrome X
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One of the biggest warning signs that you may have leaky gut — I recommend that you take a leaky gut test — can be that you’re experiencing multiple food sensitivities. Partially digested protein and fat can seep through your intestinal lining, making their way into your bloodstream and causing an allergic response.
This allergic response doesn’t mean you’ll break out in a rash all over your body, but it can lead to one of the symptoms I’ve mentioned above. If left un-repaired, it can lead to more severe health issues like inflammatory bowel disease, IBS, arthritis, eczema, psoriasis, depression, anxiety, migraine headaches, muscle pain and chronic fatigue.
According to the Journal of Diabetes, there is a strong body of evidence pointing to leaky gut syndrome as a major cause of autoimmune diseases, including Type 1 Diabetes.
Another problem with leaky gut is that it can cause malabsorption of vital minerals and nutrients including zinciron and vitamin B12.

What Causes Leaky Gut?

There are four main causes of leaky gut which include:
  • Poor diet
  • Chronic stress
  • Toxin overload
Bacterial imbalance
The most common components of food that can damage your intestinal lining are the proteins found in un-sprouted grains, sugar, GMO’s and conventional dairy.The problem with un-sprouted grains is that they contain large amounts of antinutrients or nutrient blockers called phytates and lectins. Lectins are sugar-binding proteins that act as a natural defense system for plants that protect them from outside invaders like mold and parasites.
This is good news for plants but bad news for your body. Your digestive lining is covered with sugar-containing cells that help break down your food. Lectins gravitate toward this area and when they attach to your digestive lining, it damages your gut and causes inflammation.

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Lectins and Foods that Cause Leaky Gut

Lectins are found in many foods, not just grains, and consumed in smaller amounts, your body will do just fine with them. But foods that have large amounts of lectins are more problematic. Some of the lectins and foods that cause leaky gut include wheat, rice, spelt and soy.
Sprouting and fermenting grains reduces phytates and lectins, making these foods easier to digest. GMO and hybridized foods tend to be the highest in lectins since they have been modified to fight off bugs. Also, gluten-containing grains will damage your intestinal lining and cause leaky gut syndrome.
So while you are working to heal leaky gut and cure autoimmune disease, stay away from all grains, especially ones that contain gluten like wheat. Once your gut is healthy, you can add back in grains that have been fermented and sprouted to eat occasionally.
Conventional cows milk is another food that can cause leaky gut. The component of dairy that will harm your gut is the protein A1 casein. Also, the pasteurization process will destroy vital enzymes, making sugars like lactose very difficult to digest. For this reason, I only recommend buying dairy that is raw and from A2 cows, goats, sheep, or buffalo.
Sugar is another substance that will wreak havoc on your digestive system. Sugar will feed the growth of yeast, candida and bad bacteria, which will further damage your gut. Bad bacteria actually creates toxins called exotoxins that damage healthy cells and can eat a hole into your intestinal wall.

Other Factors that Cause Leaky Gut

Chronic stress: It weakens your immune system over time, which cripples your ability to fight off foreign invaders like bad bacteria and viruses, leading to inflammation and leaky gut. To reduce stress, I recommend getting more sleep, schedule fun into your week, rest one day a week, meditate on scripture, and hang out with positive, uplifting people.
Toxins: We come into contact with over 80,000 chemicals and toxins every single year, but the worst offenders for causing leaky gut include antibiotics, pesticides, tap water, aspirin and NSAIDS. I recommend buying a high-quality water filter to eliminate chlorine and fluoride and look to natural plant-based herbs to reduce inflammation in your body.
Dysbiosis: Finally, one of the leading causes of leaky gut is a condition calleddysbiosis, which means an imbalance between beneficial and harmful species of bacteria in your gut. For many, this imbalance can begin at birth because of a C-section or because the mother didn’t have a healthy gut herself. The overuse of prescription antibiotic drugs, tap water with chlorine and fluoride, and the lack of probiotic-rich foods contribute to this imbalance of good and bad bacteria.

Leaky Gut and the Brain

Another topic I want to quickly discuss is how leaky gut can affect the brain. If you’ve ever seen a child with autism experience a mood swing, this can be caused by intestinal permeability. Gluten-free and casein-free diets have proven effective for many children with autism because these proteins can leak through the gut and then recirculate and act on the brain similarly to an opioid drug.
This is also why leaky gut syndrome has been linked to other psychological disorders such as anxiety, depression and bipolar disorder. So, in many cases, if you can heal the gut, you can heal the brain.

The 4-Step Plan to Heal Leaky Gut

The good news is there’s a solution to successfully healing leaky gut. There is a four-step process that includes:
  1. REMOVE foods and factors that damage the gut

  2. REPLACE with healing foods

  3. REPAIR with specific supplements

  4. REBALANCE with probiotics

Here’s the protocol I have used with my patients over the years that has helped them see incredible results.
Remember, the top foods to remove that cause leaky gut are sugar, grains, conventional meat, conventional dairy and GMO foods. The top toxic exposures to eliminate are tap water, pesticides, NSAIDS and antibiotics — but remember to always consult with your physician if he or she has prescribed these for you.

The Leaky Gut Diet and 5 Healing Foods

If you suffer from leaky gut syndrome, you’re overdue to consider adopting a leaky gut diet. Here are the five foods and supplements to heal your leaky gut.
#1 Bone Broth – broth contains collagen and the amino acids proline and glycine that can help heal your damaged cell walls. I’ve had many of my patients do a bone broth fast for three days to help heal leaky gut and cure autoimmune disease.
#2 Raw Cultured Dairy – contains both probiotics and SCFA’s that can help heal the gut.  Pastured kefir, yogurt, amasai, butter and raw cheese are some of the best.
#3 Fermented Vegetables – contain organic acids that balance intestinal pH and probiotics to support the gut. Sauerkraut, kimchi and kvass are excellent sources.
#4 Coconut Products – all coconut products are especially good for your gut. The MCFA’s in coconut are easier to digest than other fats so they work well for leaky gut. Also, coconut kefir contains probiotics that support your digestive system.
#5 Sprouted Seeds – chia seeds, flaxseeds and hemp seeds that have been sprouted are great sources of fiber that can help support the growth of beneficial bacteria. But if you have severe leaky gut, you may need to start out getting your fiber from steamed vegetables and fruit.
Also, consuming foods that have omega-3 fats are beneficial — anti-inflammatory foods like grass-fed beef, lamb and wild-caught fish like salmon.

Top 5 Supplements for Healing Leaky Gut

There are many supplements that support your digestive health, but I believe the most beneficial leaky gut supplements are l-glutamine, probiotics, digestive enzymes, aloe vera juice, quercetin, NAG and licorice root.
#1 Probiotics are the most important supplement to take because it helps replenish good bacteria and crowds out bad bacteria. I recommend getting probiotics in both food and supplement form. I see people all the time only follow part of the protocol in healing their leaky gut syndrome by removing the damaging irritants. But the part they often leave out is re-inoculating their gut with beneficial bacteria that will keep bad bacteria at bay.
So load up on BOTH probiotic-rich foods and take AT LEAST 50 billion units of probiotics daily from a high-quality brand.
#2 Digestive enzymes (one or two capsules at the beginning of each meal) ensure that foods are fully digested, decreasing the chance that partially digested foods particles and proteins are damaging your gut wall.
#3 L-Glutamine is critical for any program designed to heal leaky gut. Glutamine powder is an essential amino acid supplement that is anti-inflammatory and necessary for the growth and repair of your intestinal lining. L-glutamine benefits include acting as a protector: coating your cell walls and acting as a repellent to irritants. Take 2–5 grams twice daily.
#4 Licorice Root (DGL) is an adaptogenic herb that helps balance cortisol levels and improves acid production in the stomach. DGL supports the body’s natural processes for maintaining the mucosal lining of the stomach and duodenum. This herb is especially beneficial if someone’s leaky gut is being caused by emotional stress. Take 500 milligrams twice daily.
#5 Quercetin has also been shown to improve gut barrier function by sealing the gut because it supports creation of tight junction proteins. It also stabilizes mast cells and reduces the release of histamine, which is common in food intolerance. New studies have also shown its effectiveness in healing ulcerative colitis. Take 500 milligrams three times daily with meals.
If you can follow the above protocol, you are well on your way to successfully treating your gut for good.



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