Understanding your genetic clock and how to slow it down

For many years, it was thought that cells were immortal if provided an ideal environment. That belief was discarded in the early 1960s when Leonard Hayflick, PhD, observed that human fibroblasts in tissue culture wouldn’t divide more than about 50 times. Hayflick found that if he froze the cells after 20 divisions, they would “remember” that they had 30 doublings left after they thawed.

Researchers also noted that fibroblasts begin looking old as they approach 50 cell divisions. They become larger and accumulate an increased amount of lipofuscin, the pigment responsible for “age spots.” Based on Hayflick’s findings, experts theorized that there is a genetic clock within each cell that determines when old age sets in.

Currently, many researchers in the field are working with what’s known as the “telomere shortening” theory of aging. Telomeres are the end-cap segments of DNA. Each time a cell replicates, a small piece of DNA is removed from the telomere—and the shorter the telomere gets, the more gene expression is affected. The result is cellular aging.

In addition to serving as a clock for aging, the telomere is involved in protecting the end of the chromosome from damage, controlling gene expression, and aiding in the organization of the chromosome. The telomere not only determines the aging of the cell, but also its risk for cancer, Alzheimer’s disease, and other degenerative diseases.

Slowing Down the Clock

The key to extending human lifespan will ultimately involve preserving or restoring telomere length to the DNA. But that technology is decades away. Luckily, there are low-tech ways to help slow down

our genetic clocks right now, including:

• Managing stress
• Exercising regularly
• Sleeping at least 8 hours per night
• Maintaining ideal body weight
• Consuming a diet rich in vegetables and fruits
• Eating mostly low-glycemic foods
• Taking a daily multivitamin/multimineral
• Getting an optimal amount of omega-3 fatty acids from fish and fish oil supplements
• Taking additional vitamin D, polyphenols, flavonoids, and other key nutrients
• 
  

A Closer Look

Research has shown that many nutrients help fight telomere shortening, especially B vitamins such as folic acid, vitamin B12, and niacin; zinc; magnesium; and vitamins C and E. The best way to insure adequate intake of these and other nutrients is to take a quality multivitamin/multimineral supplement. Should you take iron in your multi? Unless you have a significant need for iron or are a menstruating woman, do your best to avoid iron supplements. Taking iron has been associated with shorter telomeres. Excess iron can also act to increase free radical activity.

Taking extra vitamin D is a good idea, as well—most experts now recommend at least 2,000 IU daily. In one study, scientists examined the effects of vitamin D on the length of telomeres in the white blood cells of 2,160 women aged 18—79 years. The higher their vitamin D levels, the longer the telomere length.

In terms of aging, there was a five-year difference in telomere length in those with the highest levels of vitamin D compared to those with the lowest levels. Obesity, smoking, and lack of physical activity can shorten telomere length, but researchers found that increasing vitamin D levels overcame these effects. What this five-year difference means is that a 70-year-old woman with higher vitamin D levels would have a biological age of 65 years.

Fish oils are also important to slowing the genetic clock. Higher levels of the omega-3 fatty acids EPA and DHA have been shown to reduce telomere shortening in a long-term study. The recommended dosage of fish oils is based upon providing a daily intake of 1,000 mg EPA and DHA.

Lastly, the flavonoids and polyphenols in grape seed, pine bark (Pycnogenol), and green tea are associated not only with reducing markers of inflammation, but also with preventing telomere shortening in experimental studies. The dosage recommendation for extracts providing at least 90 percent polyphenols is 150—300 mg daily.

The Insulin Angle

But perhaps the biggest cause of premature telomere shortening in North America is resistance to the hormone insulin that occurs in obesity, prediabetes, and type 2 diabetes, as recent studies have documented that insulin resistance is associated with shorter telomeres. Achieving ideal body weight and utilizing strategies to increase the sensitivity of the body cells to insulin is a critical goal to preventing telomere shortening.

You can find all supplements from article at IHERB.COM

Supplements for Fibromyalgia

If you've got pain, tiredness, and sleep trouble that go along with fibromyalgia, you may wonder if supplements can give you some relief. 

"While research on certain supplements is promising, it's still too early to say for sure if they help," says Kevin Fleming, MD, medical director of the Fibromyalgia and Chronic Fatigue Clinic at the Mayo Clinic.

Choosing a Supplement

Before you decide to take one, check with your doctor. And always do your homework.

"You want to make sure that the benefits are worth the cost," Fleming says. "Consider how long a supplement has been used for fibromyalgia symptoms."

He says newer supplements that have become popular in the past 3 or 4 years don't have a lengthy track record, so the long-term effects aren't known. 

Some common supplements that some people use:

Vitamin D. Experts aren't sure exactly why, but they think that you can get muscle and bone pain if you don't get enough of this nutrient.

In one study, researchers gave people with fibromyalgia who had low levels of vitamin D a daily supplement or a placebo (a dummy pill) for about 6 months. Those who took the supplement had less pain and fatigue.

"If you have fibromyalgia, ask your doctor for a blood test to check your vitamin D," Fleming says. If it's low, a supplement can raise your levels. But don't take a high-dose pill without your doctor's OK. More than 4,000 IU a day can lead to health problems, such as heart and kidney damage.

SAM-e. It's a substance that's found naturally in your body. It blocks cytokines, proteins in the body that cause inflammation, Fleming says. "It may also help boost mood, which can help you better handle the pain."

Danish researchers found that taking 800 milligrams every day for 6 weeks helped cut pain, fatigue, and tenderness in people with fibromyalgia.

There are few side effects from SAM-e, but you should avoid it if you have bipolar disorder because it may worsen symptoms of mania. 

Turmeric. For centuries, this spice has been used in traditional Chinese medicine to relieve arthritis pain and other conditions. Modern-day science shows that the active compound in it, called curcumin, may help fight inflammation.

Although there's little research on turmeric for fibromyalgia, it may be worth a try since curcumin works like a pain reliever in the body.

Magnesium. A common mineral found in leafy greens, nuts, and whole grains, it plays an important role in muscle and nerve function. Some experts believe supplements may help ease the muscle pain, stiffness, and cramping caused by fibromyalgia.

One small study shows that women who took 300 milligrams of the mineral a day had less tenderness and depression after 2 months.

While more research is needed, magnesium is safe for most people. The main side effects are stomach problems, like diarrhea.

5-HTP. This natural substance gets changed in your body to serotonin, a brain chemical that influences your mood, sleep, and how much pain you can put up with.

Research shows that people with fibromyalgia tend to have low levels of serotonin. One study shows that people who took 100 milligrams of 5-HTP three times a day improved their symptoms, including pain, sleep, anxiety, and stiffness, after one month. 

"The effect of 5-HTP on fibromyalgia isn't yet well understood, but what we do know makes sense," Fleming says. "I wouldn't yet recommend for my patients to definitely take this supplement." But there is little risk, he says, so he wouldn't tell people who already take the supplement to stop.

Capsaicin. You might be able to reduce the amount of pain signals your nerves fire off if you spread a cream with this chemical onto your skin.

Research shows it may ease fibromyalgia in the short term. In one study, people who used it on the skin three times a day had less pain.

"Capsaicin may be helpful, but it's limited to the area where you apply the cream," Fleming says. "So if you're experiencing pain throughout your entire body, it may not be the best treatment."

Melatonin. It's a natural hormone made by your body that affects your sleep cycle. Because fibromyalgia can disrupt your shut-eye, you may get a better night's rest if you take melatonin supplements.

"Not getting enough quality sleep can worsen your pain over time," Fleming says. One small study found that fibromyalgia patients who took 3 milligrams of melatonin at bedtime had better sleep and less pain after 1 month, although the researchers say more study is needed.

What's the Best Way to Start Taking a Supplement?

Once you get the go-ahead from your doctor, try one new supplement at a time.

"If you take a bunch all at once and experience a side effect, you won't be able to tell which one is to blame," Fleming says.

He recommends you try out a supplement for at least 2 to 3 weeks to make sure you don't have any reactions before you add another one.

You can find all supplements from article at IHERB.COM

Vitamin D

SAM-e

Turmeric

Magnesium

5-HTP

Capsaicin

Melatonin

Colloidal Silver Benefits

1. Antibacterial

First, colloidal silver’s ability to control antibiotic-resistant superbugs is astonishing. While employed at UCLA Medical School in the 1980s, Larry C. Ford, MD, documented over 650 different disease-causing pathogens that were destroyed in minutes when exposed to small amounts of silver. 

Colloidal silver, unlike its modern prescription antibiotic counterpart, simply doesn’t create resistance or immunity in the organisms that are killed by it. This point cannot be emphasized enough, especially in light of the Centers for Disease Control and Prevention (CDC) recently reporting that more than 2 million people in the U.S. suffer illness every year as a result of antibiotic-resistant infections and 23,000 die from these infections. 

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2. Wound Care/Skin Health

Robert O. Becker, MD, says that colloidal silver stimulates healing in the skin and other soft tissues. In a research article produced by Pharmacognosy Communications in 2012, it was specifically recommended that certain colloidal silver preparations should be considered for topical use to treat burns, thrush, periodontitis and other conditions.

For instance, you can treat ringworm (Tinea capitis) at home with colloidal silver because it’s a potent anti-fungal. Caused by a fungus that lives on the top layer of the skin, ringworm presents as round, scaly patches. It’s contagious and spread by skin contact and by contaminated materials, such as clothing.

Colloidal silver benefits many skins conditions such as psoriasis and eczema as well. It’s soothing to scrapes and even repairs tissue damage from burns.

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3. Pink Eye/Ear Infections 

Pink eye is an inflamed mucous membrane that covers the eyeball and eyelid lining, and it’s primarily caused by a bacterial or viral infection. Colloidal silver can be used for prompt action against this irritating and highly infectious virus and bacteria.

When applied on the infected eye, the tiny silver colloids pick up the infected cells by attracting them electromagnetically and sending them into the bloodstream to be eliminated.

Our modern prescription antibiotic drugs are designed to work against specific classes of bacteria, but ear infections may be caused by multiple classes of bacteria or can even be fungal.

In this case, the prescription antibiotic will be useless, whereas colloidal silver is effective regardless of what may be causing your infection.

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4. Antiviral

Colloidal silver benefits can be experienced as an anti-viral for HIV/AIDS, pneumonia, herpes, shingles and warts. Dr. Martin Hum, from the Institute for Optimum Nutrition, lists colloidal silver as one of the natural remedies to stop viruses fast.

Colloidal silver suffocates the virus and can even reduce the activity of the HIV virus in AIDS patients. There are also numerous anecdotal accounts of colloidal silver’s efficacy against the hepatitis C virus.

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5. Anti-Inflammatory

Colloidal silver is also a fantastic anti-inflammatory remedy. Case in point: Researchers at the National Institutes of Health (NIH) studied the effects of inflammation after being treated by colloidal silver; they found that the inflamed skin of pigs treated with silver experienced near-normal skin after 72 hours, while other treatment groups not treated with silver remained inflamed. 

Research is beginning to reflect what many people have already known anecdotally for years — that colloidal silver can reduce swelling, speed healing, and boosts cell recovery!

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6. Sinusitis

Widely used to control sinus infections, colloidal silver can benefit people as a nasal spray, according to a study published in the International Forum for Allergy and Rhinology last year. 

Specifically shown to kill Staph aureus, you can add a few drops of silver in a “neti pot” or by applying directly into your nasal cavity and letting it drain down your throat by tilting your head back.

Also, it’s important to point out that recent research indicates that hidden infections by pathogens could be a cause of respiratory inflammation associated with common allergies and asthma. Colloidal silver destroys Pseudomonas aeruginosa infections, which may be the reason why airborne allergy sufferers often find such dramatic relief from colloidal silver.

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7. Cold/Flu

Some claim that colloidal silver helps prevent all types of flu, including swine flu, as well as the common cold. 

Few studies have been done to test this clinically, but in 2011 the NIH took 100 children under the age of 12 suffering from the common cold and nasal congestion and assigned them into two groups; the first group was treated with a solution of colloidal silver and beta glucan, and the second group with saline solution. Even though both groups benefited from the treatment, 90% of the people in the colloidal silver group completely recovered! 

8. Pneumonia 

Our modern drugs have become limited in their efficacy when it comes to fighting bronchitis or pneumonia. Typically, antibiotics are administered as the first line of defense, but when the pneumonia is viral, antibiotics won’t help in the least. The nice thing about colloidal silver is that it can help regardless of the pathogen.

Colloidal silver is a remarkable product to help fight against bronchitis and pneumonia when ingested internally, but an even more effective way to utilize it? Simply breathe it into your lungs.

This way, the silver directly contacts the germs residing in the lungs, which are causing bronchitis or pneumonia. It’s basically the same thing as using respiratory support, and it works speedily, clearing it up within a couple of days.

Now, the most effective method to get the colloidal silver into the lungs is to use a nebulizer. Generally, use one teaspoon approximately three times a day for 10 to 15 minutes.

Colloidal Dosage & Use

Colloidal silver needs to be applied differently for each condition. To experience colloidal silver benefits, it may be taken as follows, always keeping in mind to never use it for more than 14 days in a row.

• 2-5 drops applied directly to the skin
• 1 eyedropper taken orally for immune support
• 1-2 drops into eyes for pink eye
• 1-2 drops can help disinfect any wound or sore by applying onto a Band-Aid
• If prepared properly, it can be injected into a muscle, a cancerous tumor, or into the bloodstream
• 5 drops added into a neti pot or directly sprayed into the nose
• 5-10 drops can be applied vaginally or anally

You can find biggest selection of Colloidal Silver products at IHERB.COM

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